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Smoking linked to permanent genetic damages

04/13/99

In a press conference at the Anderson Cancer Institute, Dr. Gazdar said that the molecular damage caused by smoking never goes away - even after quitting smoking. However, the damage is not as high as that in the lungs of people who continue to smoke. A second study conducted by Dr. Curtis Harris and team of the National Cancer Institute revealed similar results. The investigators specifically looked for mutations of the p53 gene -- a tumor suppressor gene that is damaged by smoking in a way that can lead to cancer. In a report presented to the American Association for Cancer Research, results showed that even after 15 years of smoking cessation, ex-smokers had a p53 mutation frequency.

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