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American cigarette manufacturers have filed a lawsuit against the FDA.
The largest US tobacco companies filed a lawsuit in the US District Court for the District of Columbia against the Federal Office of the Food and Drug Administration (FDA).
read more ...05/04/15
Interesting facts about cigarettes, countries - tobacco leaders.
Every minute in the world are sold about 8-10 million cigarettes and daily 13-15 billion cigarettes.
read more ...04/01/15
Anti-smoking campaigns run to extremes.
It is strange to what can bring the foolishness of anti-smoking crusaders in their attempts to impose all the rules of a healthy lifestyle, even if they lead to a violation of all norms, artistic freedom and civil society.
read more ...03/03/15
Lethal effect of smoking on oocytes clarified


WESTPORT, CT (Reuters Health) - The polycyclic aromatic hydrocarbons (PAHs) found in tobacco smoke and elsewhere induce oocyte death by activating a preexisting apoptotic pathway rather than through some nonspecific toxic effect, according to a report pub

Cigarette smoking has been linked to early menopause, and animal studies have shown that PAHs induce oocyte death, but until now, the mechanisms involved were unclear, the authors state. Dr. Jonathan Tilly, from Massachusetts General Hospital in Boston, and colleagues found that treating female mice with PAH compounds led to oocyte expression of Bax, a gene previously shown to initiate apoptosis. Further analysis revealed that the PAHs bind to an oocyte surface receptor known as the aromatic hydrocarbon receptor (Ahr), which then enters the nucleus to stimulate Bax expression. Mice that were engineered to lack the Bax gene or the Ahr gene did not show oocyte death when exposed to PAHs, the researchers note. To gauge the importance of the findings for humans, the researchers grafted human ovarian tissue under the skin of mice. Once again, a striking Bax-driven increase in degenerating oocytes was noted after treatment with the PAH compounds. "We have been very interested for many years in the things that drive menopause," Dr. Tilly told Reuters Health. "With the link that has been established between smoking and early menopause, it raised some questions that the chemicals present in cigarette smoke may influence some apoptotic pathway." "The Ahr evolved about 450 million years ago, but its natural ligand has remained elusive," Dr. Tilly pointed out. "No one knows what naturally stimulates this receptor, but the PAHs can subserve this role and pharmacologically turn the receptor on," he said. "We have studied Bax-dependent apoptosis for several years and we've developed strategies for protecting the oocyte from this type of insult," Dr. Tilly noted. "Now that we know PAH binding of Ahr is tied to Bax-driven apoptosis, we can apply many of the protective strategies that we've already developed."

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